Ketamine Therapy

Common services and transparent pricing

Pricing estimates are modeled from the current OpenDoc specialty taxonomy, visit archetypes, and transparent cash-pay assumptions. Posted provider pricing should be treated as the source of truth whenever it is available. Pricing last reviewed April 8, 2026.

• Initial Psychiatric Evaluation for Ketamine — $150–$350: Initial Psychiatric Evaluation for Ketamine is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• IV Ketamine Infusion (Single Session) — $400–$800: IV Ketamine Infusion (Single Session) is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• IV Ketamine Infusion Series (6 Sessions) — $2400–$4200: IV Ketamine Infusion Series (6 Sessions) is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• Ketamine Booster Infusion — $400–$700: Ketamine Booster Infusion is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• Spravato (Esketamine Nasal Spray) Session — $600–$1200: Spravato (Esketamine Nasal Spray) Session is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• Intramuscular (IM) Ketamine Session — $250–$500: Intramuscular (IM) Ketamine Session is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• Ketamine-Assisted Psychotherapy (KAP) — $500–$1000: Ketamine-Assisted Psychotherapy (KAP) is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• Integration Therapy Session — $125–$250: Integration Therapy Session is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• Follow-Up / Maintenance Visit — $100–$200: Follow-Up / Maintenance Visit is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.
• At-Home Ketamine Prescription (Sublingual/Troches) — $200–$400: At-Home Ketamine Prescription (Sublingual/Troches) is a common ketamine therapy entry point on OpenDoc with transparent pricing before booking.

Frequently asked questions

How much does ketamine therapy cost without insurance?

A single IV ketamine infusion costs $400–$800 on OpenDoc. The standard initial protocol is 6 infusions over 2–3 weeks, costing $2,400–$4,200 total. Booster infusions are then scheduled as needed, typically every 4–8 weeks. Intramuscular ketamine and at-home sublingual options are lower-cost alternatives ranging from $200–$500 per session.

Is ketamine therapy covered by insurance?

IV ketamine for depression is not covered by most insurance plans, as it remains an off-label use. Spravato (esketamine nasal spray) is FDA-approved and may be partially covered, but often requires prior authorization and must be administered in a certified clinic with 2-hour monitoring. Cash-pay ketamine therapy on OpenDoc avoids these barriers entirely.

How quickly does ketamine work for depression?

Many patients notice improvement within hours to days of their first infusion — significantly faster than traditional antidepressants that take 4–6 weeks. The full 6-session protocol typically produces the most robust and sustained response. About 70% of patients with treatment-resistant depression respond to IV ketamine, though individual results vary.

What is the difference between IV ketamine and Spravato?

IV ketamine uses racemic ketamine (both S and R forms) administered intravenously with precise dose control. Spravato is a nasal spray containing only esketamine (the S form), FDA-approved specifically for treatment-resistant depression. Spravato requires a REMS-certified clinic and 2-hour monitoring. IV ketamine offers more dosing flexibility and is generally less expensive per session.

Is ketamine therapy safe?

Ketamine has been used safely in medicine since 1970 as an anesthetic. At subanesthetic doses used for depression, common side effects include temporary dissociation, nausea, dizziness, and elevated blood pressure — all monitored during your session. Serious adverse events are rare when administered by trained clinicians with proper vital sign monitoring.

How many ketamine sessions do I need?

The standard induction protocol is 6 IV infusions over 2–3 weeks. After the initial series, most patients transition to maintenance boosters every 4–8 weeks. Some patients maintain their response for months between boosters, while others need more frequent sessions. Your provider will develop a personalized maintenance schedule based on your response.

What is integration therapy and do I need it?

Integration therapy is a psychotherapy session — typically 50 minutes — conducted between or after ketamine treatments to help you process insights and emotions that arise during infusions. While not strictly required, research suggests that combining ketamine with psychotherapy produces more durable results than ketamine alone. Many clinics on OpenDoc include or offer integration sessions.

Can I drive home after a ketamine infusion?

No. You must arrange for someone to drive you home after every ketamine session. The dissociative and sedating effects typically resolve within 1–2 hours post-infusion, but you should not drive, operate machinery, or make important decisions for the remainder of the day. Plan to have a quiet evening at home after your session.